What is a specific part of a video game that made you quit playing that game?

Any time it feels like the physical action required to play the starts to feel like a chore just to interact with the game as designed. Like hold buttons to interact with common features or complex submenus where you need to navigate a 3+ button combo where you hold the first then the second then press the third to perform a common action.

THIS. OMG. Pressing down the left stick to sprint is fucking awful. Worst feeling button.